The clinical course of childhood and adolescent adrenoleukodystrophy before and after Lorenzo's oil

被引：8

作者：

Suzuki, Y ^{[1
]}

Imamura, A ^{[1
]}

Shimozawa, N ^{[1
]}

Kondo, N ^{[1
]}

机构：

[1] Gifu Univ, Sch Med, Dept Pediat, Gifu 5008705, Japan

来源：

BRAIN & DEVELOPMENT | 2001年 / 23卷 / 01期

关键词：

X-linked adrenoleukodystrophy; natural course; Kaplan-Meier analysis;

D O I：

10.1016/S0387-7604(00)00196-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The clinical course of Japanese patients with childhood and adolescent adrenoleukodystrophy (ALD) who were treated with Lorenzo's oil after the progression of early symptoms was investigated by Kaplan-Meier analyses. Many of the early symptoms, including visual, personality, hearing, mental and speech disturbances, had already appeared when the oil therapy was started. These early symptoms appeared significantly faster than bed-ridden state or dysphagia (P < 0.01). Gait disturbance appeared faster than bed-ridden state and dysphagia (P < 0.05), and tended to appear later than the early symptoms. These results would reflect the early natural course of childhood and adolescent ALD before treatment, and provide a basis for the evaluation of therapeutic trials for ALD. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：30 / 33

页数：4

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