Response to Comment on "Oscillations in NF-κB signaling control the dynamics of gene expression"

被引：45

作者：

Nelson, DE

Horton, CA

See, V

Johnson, JR

Nelson, G

Spiller, DG

Kell, DB

White, MRH

机构：

[1] Univ Liverpool, Sch Biol Sci, Ctr Cell Imaging, Liverpool L69 3ZB, Merseyside, England

[2] Univ Manchester, Dept Chem, Manchester M60 1QD, Lancs, England

来源：

SCIENCE | 2005年 / 308卷 / 5718期

关键词：

D O I：

10.1126/science.1108198

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Our experimental data shows no correlation between NF-kappa B (ReLA) expression level and oscillation dynamics. We show that a small change to the computational model used by Barken et al. to generate their theoretical data reduces the apparent discrepancies. Cell system differences and possible compensatory changes to normal signaling in their genetically engineered knockout cells may explain differences between the two studies.

引用

页数：3

共 16 条

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