Reduced cardiac vagal activity in obese children and adolescents

P>Objective: Obese children present with various cardiovascular risk factors affecting their future health. In adults, cardiac autonomic function is a major risk factor, predicting cardiovascular morbidity and mortality. We hypothesized that obese children and adolescents had a lower cardiac vagal activity than lean subjects. We measured cardiac spontaneous baroreflex sensitivity (BRS), reflecting the dynamic regulation of cardiac vagal function, in large groups of obese and lean young individuals. Methods and results: Cardiac BRS, using the sequence approach, was assessed in 120 obese (59 girls), 43 overweight (23 girls) and 148 lean subjects (78 girls). Obese subjects showed a decreased BRS compared to both overweight and lean subjects [16 +/- 7 versus 21 +/- 9 (P < 0 center dot 01) and 22 +/- 10 ms per mmHg (P < 0 center dot 0001), respectively]. The differences remained after correcting for age, gender and pubertal status. Conclusion: Children with obesity had low vagal activity at rest, and there was no gender difference.