Chromatin dynamics and gene positioning

被引：117

作者：

Kumaran, R. Ileng ^{[1
]}

Thakar, Rajika ^{[1
]}

Spector, David L. ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

CELL | 2008年 / 132卷 / 06期

关键词：

D O I：

10.1016/j.cell.2008.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mammalian cell nucleus provides a landscape where genes are regulated through their organization and association with freely diffusing proteins and nuclear domains. In many cases, specific genes are highly dynamic, and the principles governing their movements and interchromosomal interactions are currently under intensive study. Recent investigations have implicated actin and myosin in chromatin dynamics and gene expression. Here, we discuss our current understanding of the dynamics of the interphase genome and how it impacts nuclear organization and gene activity.

引用

页码：929 / 934

页数：6

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