Chromatin dynamics and gene positioning

被引：117

作者：

Kumaran, R. Ileng ^{[1
]}

Thakar, Rajika ^{[1
]}

Spector, David L. ^{[1
]}

机构：

[1] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA

来源：

CELL | 2008年 / 132卷 / 06期

关键词：

D O I：

10.1016/j.cell.2008.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mammalian cell nucleus provides a landscape where genes are regulated through their organization and association with freely diffusing proteins and nuclear domains. In many cases, specific genes are highly dynamic, and the principles governing their movements and interchromosomal interactions are currently under intensive study. Recent investigations have implicated actin and myosin in chromatin dynamics and gene expression. Here, we discuss our current understanding of the dynamics of the interphase genome and how it impacts nuclear organization and gene activity.

引用

页码：929 / 934

页数：6

共 42 条

[31] The locus control region is required for association of the murine β-globin locus with engaged transcription factories during erythroid maturation [J].

Ragoczy, Tobias ;

Bender, M. A. ;

Telling, Agnes ;

Byron, Rachel ;

Groudine, Mark .

GENES & DEVELOPMENT, 2006, 20 (11) :1447-1457

[32]

REDDY KL, 2008, NATURE 0213, V13, P2008, DOI DOI 10.1038/NATURE06727

[33] Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse [J].

Serizawa, S ;

Miyamichi, K ;

Nakatani, H ;

Suzuki, M ;

Saito, M ;

Yoshihara, Y ;

Sakano, H .

SCIENCE, 2003, 302 (5653) :2088-2094

[34] Gene regulation through nuclear organization [J].

Sexton, Tom ;

Schober, Heiko ;

Fraser, Peter ;

Gasser, Susan M. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2007, 14 (11) :1049-1055

[35] Regulation of odorant receptors: one allele at a time [J].

Shykind, BM .

HUMAN MOLECULAR GENETICS, 2005, 14 :R33-R39

[36] Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes [J].

Skok, Jane A. ;

Gisler, Ramiro ;

Novatchkova, Maria ;

Farmer, Deborah ;

de Laat, Wouter ;

Busslinger, Meinrad .

NATURE IMMUNOLOGY, 2007, 8 (04) :378-387

[37] The dynamics of chromosome organization and gene regulation [J].

Spector, DL .

ANNUAL REVIEW OF BIOCHEMISTRY, 2003, 72 :573-608

[38] Regulation of V(D)J recombination [J].

Spicuglia, S ;

Franchini, DM ;

Ferrier, P .

CURRENT OPINION IN IMMUNOLOGY, 2006, 18 (02) :158-163

[39] Interchromosomal associations between alternatively expressed loci [J].

Spilianakis, CG ;

Lalioti, MD ;

Town, T ;

Lee, GR ;

Flavell, RA .

NATURE, 2005, 435 (7042) :637-645

[40] The role of chromatin structure in regulating the expression of clustered genes [J].

Sproul, D ;

Gilbert, N ;

Bickmore, WA .

NATURE REVIEWS GENETICS, 2005, 6 (10) :775-781

← 1 2 3 4 5 →