Individual cerebral metabolic deficits in Alzheimer's disease and amnestic mild cognitive impairment: an FDG PET study

被引:88
作者
Del Sole, Angelo [1 ]
Clerici, Francesca [2 ]
Chiti, Arturo [3 ]
Lecchi, Michela [1 ]
Mariani, Claudio [2 ]
Maggiore, Laura [2 ]
Mosconi, Lisa [4 ]
Lucignani, Giovanni [1 ]
机构
[1] Univ Milan, Hosp San Paolo, Nucl Med Unit, Inst Radiol Sci, I-20142 Milan, Italy
[2] Univ Milan, Luigi Sacco Hosp, Dept Clin Sci, Ctr Res & Treatment Cognit Dysfunct,Inst Clin Neu, I-20142 Milan, Italy
[3] Clin Inst Humanitas, Dept Nucl Med, Milan, Italy
[4] NYU, Sch Med, Dept Psychiat, New York, NY USA
关键词
cerebral glucose metabolism; Alzheimer's disease; dementia; mild cognitive impairment; positron emission tomography;
D O I
10.1007/s00259-008-0773-6
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose The purpose of the study was the identification of group and individual subject patterns of cerebral glucose metabolism (CMRGlu) in patients with Alzheimer's disease (AD) and with amnestic mild cognitive impairment (aMCI). Methods [F-18]fluorodeoxyglucose positron emission tomography (PET) studies and neuropsychological tests were performed in 16 aMCI patients (ten women, age 75 +/- 8 years) and in 14 AD patients (ten women, age 75 +/- 9 years). Comparisons between patient subgroups and with a control population were performed using Statistical Parametric Mapping. Results Clusters of low CMRGlu were observed bilaterally in the posterior cingulate cortex (PCC), in the precuneus, in the inferior parietal lobule and middle temporal gyrus of AD patients. In aMCI patients, reduced CMRGlu was found only in PCC. Areas of low CMRGlu in PCC were wider in AD compared to aMCI and extended to the precuneus, while low CMRGlu was found in the lateral parietal cortex in AD but not in aMCI patients. Individual subject pattern analysis revealed that 86% of AD patients had low CMRGlu in the PCC (including the precuneus in 71%), 71% in the temporal cortex, 64% in the parietal cortex and 35% in the frontal cortex. Among the aMCI patients, 56% had low CMRGlu in the PCC, 44% in the temporal cortex, 18% in the frontal cortex and none in the parietal cortex. Conclusion This study demonstrates that both AD and aMCI patients have highly heterogeneous metabolic impairment. This potential of individual metabolic PET imaging in patients with AD and aMCI may allow timely identification of brain damage on individual basis and possibly help planning tailored early interventions.
引用
收藏
页码:1357 / 1366
页数:10
相关论文
共 29 条
[11]  
Kogure D, 2000, J NUCL MED, V41, P1155
[12]  
Kordower JH, 2001, ANN NEUROL, V49, P202, DOI 10.1002/1531-8249(20010201)49:2<202::AID-ANA40>3.0.CO
[13]  
2-3
[14]   Brain metabolic changes associated with predispotion to onset of major depressive disorder and adjustment disorder in cancer patients - A preliminary PET study [J].
Kumano, H. ;
Ida, I. ;
Oshima, A. ;
Takahashi, K. ;
Yuuki, N. ;
Amanuma, M. ;
Endo, K. ;
Matsuda, H. ;
Mikuni, M. .
JOURNAL OF PSYCHIATRIC RESEARCH, 2007, 41 (07) :591-599
[15]  
Lezak M, 1995, NEUROPSYCHOLOGICAL A
[16]   The role of neuroimaging in mild cognitive impairment [J].
Matsuda, Hiroshi .
NEUROPATHOLOGY, 2007, 27 (06) :570-577
[17]  
MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939
[18]   Normal and pathological aging - findings of positron-emission-tomography [J].
Mielke, R ;
Kessler, J ;
Szelies, B ;
Herholz, K ;
Wienhard, K ;
Heiss, WD .
JOURNAL OF NEURAL TRANSMISSION, 1998, 105 (8-9) :821-837
[19]   Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease [J].
Minoshima, S ;
Giordani, B ;
Berent, S ;
Frey, KA ;
Foster, NL ;
Kuhl, DE .
ANNALS OF NEUROLOGY, 1997, 42 (01) :85-94
[20]   Diagnostic and Statistical Manual of Mental Disorders [J].
Mittal, Vijay A. ;
Walker, Elaine F. .
PSYCHIATRY RESEARCH, 2011, 189 (01) :158-159