Sclerostin levels in uremic patients: a link between bone and vascular disease

被引：19

作者：

Bruzzese, Annamaria ^{[1
]}

Lacquaniti, Antonio ^{[1
]}

Cernaro, Valeria ^{[1
]}

Ricciardi, Carlo Alberto ^{[1
]}

Loddo, Saverio ^{[2
]}

Romeo, Adolfo ^{[1
]}

Montalto, Gaetano ^{[1
]}

Costantino, Giuseppe ^{[1
]}

Torre, Francesco ^{[1
]}

Pettinato, Giuseppina ^{[1
]}

Salamone, Ignazio ^{[3
]}

Aloisi, Carmela ^{[1
]}

Santoro, Domenico ^{[1
]}

Buemi, Michele ^{[1
]}

机构：

[1] Univ Messina, Dept Clin & Expt Med, Messina, Italy

[2] Univ Messina, Dept Pathol, Messina, Italy

[3] Univ Messina, Dept Biomed Sci & Morphol & Funct Imaging, Messina, Italy

来源：

RENAL FAILURE | 2016年 / 38卷 / 05期

关键词：

Acetate Free Bio-filtration; atherosclerotic disease; Chronic kidney disease-mineral and bone disorder; sclerostin; vascular calcification; SERUM SCLEROSTIN; HEMODIALYSIS; CALCIFICATION; DIALYSIS; CALCIUM;

D O I：

10.3109/0886022X.2016.1160207

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Sclerostin is a marker of low-turnover bone disease in end stage renal disease patients. The aim of this study was to evaluate serum sclerostin in uremic patients, analyzing its behavior during a single hemodialysis session. Twenty-one adult patients on intermittent hemodialysis treatment were enrolled. Acetate Free Bio-filtration (AFB) was the technique employed. Uremic patients were characterized by higher levels of serum sclerostin when compared with values observed in healthy subjects. Sclerostin assessed in pre-dialysis samples was 1.4 +/- 1.02ng/mL, whereas, in post dialysis samples, a reduction of sclerostin values was observed (0.8 +/- 0.6ng/mL; p: 0.008). Sclerostin correlated with parameters of dialysis adequacy, such as creatinine levels and Kt/V values, and it was significantly associated with atherosclerotic disease. Receiver operating characteristics analysis revealed a good diagnostic profile in identifying atherosclerotic disease. Sclerostin, a full dialyzable substance during AFB dialysis, is closely associated with atherosclerotic disease. Its reduction obtained through AFB could represent a defensive mechanism, improving vascular disease and renal osteodystrophy.

引用

页码：759 / 764

页数：6

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