Molecular genetics of uveal melanoma

被引：18

作者：

Loercher, AE ^{[1
]}

Harbour, JW ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USA

来源：

CURRENT EYE RESEARCH | 2003年 / 27卷 / 02期

关键词：

D O I：

10.1076/ceyr.27.2.69.15952

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

In the past decade, there have been impressive advances in our understanding of chromosomal, genetic and molecular alterations that occur in uveal melanoma. Nevertheless, a coherent picture of the molecular pathogenesis of this eye cancer is yet to emerge. Herein, we review the findings to date, discuss the insights they provide, and suggest future directions for molecular research in uveal melanoma.

引用

页码：69 / 74

页数：6

共 52 条

[1]

Aalto Y, 2001, INVEST OPHTH VIS SCI, V42, P313

[2] Applications of SKY in cancer cytogenetics [J].

Bayani, JM ;

Squire, JA .

CANCER INVESTIGATION, 2002, 20 (03) :373-386

[3]

Brantey MA, 2000, CANCER RES, V60, P4320

[4] Deregulation of the Rb and p53 pathways in uveal melanoma [J].

Brantley, MA ;

Harbour, JW .

AMERICAN JOURNAL OF PATHOLOGY, 2000, 157 (06) :1795-1801

[5] Altered expression of Rb and p53 in uveal melanomas following plaque radiotherapy [J].

Brantley, MA ;

Worley, L ;

Harbour, JW .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2002, 133 (02) :242-248

[6] EXPRESSION OF RECESSIVE ALLELES BY CHROMOSOMAL MECHANISMS IN RETINOBLASTOMA [J].

CAVENEE, WK ;

DRYJA, TP ;

PHILLIPS, RA ;

BENEDICT, WF ;

GODBOUT, R ;

GALLIE, BL ;

MURPHREE, AL ;

STRONG, LC ;

WHITE, RL .

NATURE, 1983, 305 (5937) :779-784

[7] c-myc, p53, and Bcl-2 expression and clinical outcome in uveal melanoma [J].

Chana, JS ;

Wilson, GD ;

Cree, IA ;

Alexander, RA ;

Myatt, N ;

Neale, M ;

Foss, AJE ;

Hungerford, JL .

BRITISH JOURNAL OF OPHTHALMOLOGY, 1999, 83 (01) :110-114

[8]

Coupland SE, 2000, J PATHOL, V191, P120

[9] A REVIEW OF MORTALITY FROM CHOROIDAL MELANOMA .2. A METAANALYSIS OF 5-YEAR MORTALITY-RATES FOLLOWING ENUCLEATION, 1966 THROUGH 1988 [J].

DIENERWEST, M ;

HAWKINS, BS ;

MARKOWITZ, JA ;

SCHACHAT, AP .

ARCHIVES OF OPHTHALMOLOGY, 1992, 110 (02) :245-250

[10] EPIDEMIOLOGIC ASPECTS OF UVEAL MELANOMA [J].

EGAN, KM ;

SEDDON, JM ;

GLYNN, RJ ;

GRAGOUDAS, ES ;

ALBERT, DM .

SURVEY OF OPHTHALMOLOGY, 1988, 32 (04) :239-251

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