Glutathione-Induced Intracellular Release of Guests from Mesoporous Silica Nanocontainers with Cyclodextrin Gatekeepers

被引：323

作者：

Kim, Hyehyeon ^{[2
]}

Kim, Saehee ^{[2
]}

Park, Chiyoung ^{[2
]}

Lee, Hyemi ^{[1
]}

Park, Heon Joo ^{[1
]}

Kim, Chulhee ^{[2
]}

机构：

[1] Inha Univ, Coll Med, Dept Microbiol, Inchon 400712, South Korea

[2] Inha Univ, Dept Polymer Sci & Engn, Inchon 402751, South Korea

来源：

ADVANCED MATERIALS | 2010年 / 22卷 / 38期

关键词：

RESPONSIVE CONTROLLED-RELEASE; DRUG-DELIVERY; PARTICLES; MOLECULES; SYSTEM;

D O I：

10.1002/adma.201001417

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cyclodextrins tethered onto a mesoporous silica nanoparticle via disulfide stalking are effective gatekeepers not only to entrap guest molecules in the pore but also to release the guest in response to glutathione (GSH). The PEGylated nanocontainers also exhibit efficient GSH-mediated release of doxorubicin in cancer cells. Our approach offers unique applications for multifunctional delivery systems.

引用

页码：4280 / +

页数：5

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