Rapid diversity-oriented synthesis in microtiter plates for in situ screening:: Discovery of potent and selective α-fucosidase inhibitors

被引：118

作者：

Wu, CY

Chang, CF

Chen, JSY

Wong, CH

Lin, CH

机构：

[1] Acad Sinica, Inst Biol Chem, Taipei 11529, Taiwan

[2] Acad Sinica, Ctr Gene Res, Taipei 11529, Taiwan

[3] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[4] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 38期

关键词：

D O I：

10.1002/anie.200351823

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and simple method has been developed to identify potent and selective inhibitors against α-fucosidases based on the amide-forming reaction in a microtiter plate of a fuconojirimycin core with various carboxylic acids, followed by a direct inhibition assay without product isolation. The structures of the two most potent inhibitors are shown.

引用

收藏

页码：4661 / 4664

页数：4

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