Anti-inflammatory activity and effect on gastric acid secretion of dehydroleucodine isolated from Artemisia douglasiana

被引：26

作者：

Guardia, T ^{[1
]}

Juarez, AO

Guerreiro, E

Guzmán, JA

Pelzer, L

机构：

[1] Natl Univ San Luis, Fac Chem Biochem & Pharm, Pharmacol Unit, Dept Pharm, RA-5700 San Luis, Argentina

[2] Natl Univ San Luis, Fac Chem Biochem & Pharm, Dept Organ Chem, RA-5700 San Luis, Argentina

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2003年 / 88卷 / 2-3期

关键词：

dehidroleucodine; Artemisia douglasiana; gastric acid; anti-inflammatory activity;

D O I：

10.1016/S0378-8741(03)00211-3

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The effect of Dehydroleucodine (DhL) on gastric acid secretion in rats was investigated at a dose of 40 mg/kg, while its anti-inflammatory effect was investigated in two experimental models: arthritis induced by Freund's adjuvant carrageenan- and cotton pellet-induced granuloma. DhL did not inhibit gastric acid secretion, suggesting that its anti-ulcerogenic effect can be attributed to its action on the mucosa defense factors. On the other hand, DhL inhibited both chronic and acute adjuvant carrageenan-induced inflammation phases, being most effective in the chronic phase. In the granuloma test, DhL also inhibited inflammation. It is suggested that the anti-inflammatory activity of DhL may be attributed to interference with multiple targets on the level of transcription factors, such as NF-kappaB, and cytokines. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：195 / 198

页数：4

共 15 条

[1] Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappa B [J].