Risk estimates for drugs suspected of being associated with Stevens-Johnson syndrome and toxic epidermal necrolysis: a case-control study

被引：68

作者：

Lin, MS

Dai, YS

Pwu, RF

Chen, YH

Chang, NC

机构：

[1] Taipei Med Univ Hosp, Sch Med, Dept Internal Med, Taipei 105, Taiwan

[2] Natl Taiwan Univ, Coll Publ Hlth, Grad Inst Epidemiol, Taipei 10764, Taiwan

[3] Natl Taiwan Univ Hosp, Dept Dermatol, Taipei, Taiwan

[4] Natl Taiwan Univ Hosp, Dept Pharm, Taipei, Taiwan

[5] STAT Healthcare Consulting Co Ltd, Taipei, Taiwan

来源：

INTERNAL MEDICINE JOURNAL | 2005年 / 35卷 / 03期

关键词：

case-control study; Stevens-Johnson syndrome; toxic epidermal necrolysis; adverse drug reaction; relative risk;

D O I：

10.1111/j.1445-5994.2005.00790.x

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The purpose of this case-control study is to estimate the risks of Stevens-Johnson syndrome or toxic epidermal necrolysis associated with the use of specific drugs. The suspected cases were identified from the computerized hospital discharge file. We calculated crude relative risks and adjusted them for confounding by multivariate analysis. The analysis was based on 35 cases and 105 controls. This study showed that the use of carbamazepine, phenytoin and allopurinol is most associated with the risks in the oriental population.

引用

页码：188 / 190

页数：3

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