What have snakes taught us about integrins?

被引:91
作者
Huang, TF [1 ]
机构
[1] Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei, Taiwan
关键词
snake venom disintegrin; metalloprotease; ADAMs; integrin alpha(IIb)beta(3); alpha(2)beta(1); alpha(v)beta(3); platelet aggregation; haemorrhage; cell-matrix interaction; cell fusion;
D O I
10.1007/s000180050181
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Snake venoms contain unique components that affect cell-matrix interactions. Disintegrins represent a class of low molecular weight, Arg-Gly-Asp (RGD)containing, cysteine-rich peptides purified from the venom of various snakes among the Viperidae and Crotalidae. They bind with various degrees of specificity to integrins alpha(IIb)beta(3), alpha(5)beta(1) and alpha(V)beta(3) expressed on cells. Snake venom metalloproteases thigh molecular mass haemorrhagins) also contain disintegrin-like domains, in addition to zinc-chelating sequences. Membrane-anchored ADAMs (A Disintegrin And Metalloprotease domain), multidomain molecules consisting of metalloprotease, disintegrin-like, cysteine-rich, and epidermal growth factor domains, a transmembrane domain and a cytoplasmic tail, are a new family of proteins. In the light of the large number and wide distribution of ADAMs, they may participate in cell-cell fusion events, including sperm-egg binding and fusion, myoblast fusion and other cell-cell and cell-matrix interactions. The structure-function relationship of these molecules is discussed.
引用
收藏
页码:527 / 540
页数:14
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