Exposure of hepatitis C virus-negative recipients to ≥2 infected blood donors

被引:14
作者
Laskus, T
Wang, LF
Radkowski, M
Nowicki, M
Wilkinson, J
Rakela, J
机构
[1] Mayo Clin Scottsdale, Dept Med, Div Transplantat Med, Scottsdale, AZ 85259 USA
[2] Univ Pittsburgh, Med Ctr, Div Gastroenterol & Hepatol, Pittsburgh, PA USA
[3] Univ So Calif, Los Angeles, CA USA
[4] Med Acad Warsaw, Inst Infect Dis, Warsaw, Poland
基金
美国国家卫生研究院;
关键词
D O I
10.1086/318531
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This study analyzed 4 cases of hepatitis C virus (HCV)-naive transfusion recipients who developed hepatitis after receiving blood from 11 HCV-infected donor. One recipient was exposed to 4 donors, 2 were exposed to 3 donors, and 1 was exposed to 2 donors. For 3 recipients, the strain from 1 of the donors predominated in all follow-up samples collected for 8-40 months. For 2 recipients, the strain from the second donor was occasionally detectable with sensitive strain-specific assays. For the fourth recipient, the initially dominant strain was later supplanted by a strain from the other donor. Simultaneous exposure to multiple HCV strains may result in concomitant infection by 11 strain, although a single strain rapidly establishes its dominance. These observations are compatible with the presence of competition among infecting HCV strains that results in the dominance of 1 strain and competitive exclusion or suppression of other strains.
引用
收藏
页码:666 / 669
页数:4
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