Functional genomnics of cardiac ion channel genes

被引：22

作者：

Demolombe, S ^{[1
]}

Marionneau, C ^{[1
]}

Le Bouter, S ^{[1
]}

Charpentier, F ^{[1
]}

Escande, D ^{[1
]}

机构：

[1] Fac Med, INSERM, U533, Inst Thorax, F-44035 Nantes, France

来源：

CARDIOVASCULAR RESEARCH | 2005年 / 67卷 / 03期

关键词：

ion channel expression; DNA microarrays; molecular remodeling; arrhythmias;

D O I：

10.1016/j.cardiores.2005.04.021

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ion channels are an ensemble of specialized membrane proteins that act in concert to create and modulate the electrical activity of many excitable cells, including cardiac myocytes. Following completion of the sequencing of various genomes, including that of the human, the complete repertoire of ion channel genes has been elucidated for different species. How transcripts issued from this gene collection are expressed and modulated in relation to variable physiological and pathological situations is the subject of functional or physiological genomics. Specialized microarrays (lonChips) comprising probes for the ensemble of ion channel and regulatory genes were developed as an alternative to whole-genome DNA chips. Physiological genomics of cardiac ion channel genes is a growing field that, in combination with genetics, should markedly increase our comprehension of the molecular mechanisms leading to arrhythmias. (C) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

引用

页码：438 / 447

页数：10

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