Correlation of intrinsic DNA curvature with DNA property periodicity

被引：84

作者：

Gabrielian, A

Pongor, S

机构：

[1] INT CTR GENET ENGN & BIOTECHNOL,I-34012 TRIESTE,ITALY

[2] RUSSIAN ACAD SCI,INST MOL BIOL,MOSCOW 117984,RUSSIA

来源：

FEBS LETTERS | 1996年 / 393卷 / 01期

关键词：

DNA structure; DNA curvature; sequence periodicity; Fourier analysis;

D O I：

10.1016/0014-5793(96)00855-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twelve di- and trinucleotide parameter sets representing various structural, thermodynamic or bendability-related properties of DNA were tested in the prediction of DNA curvature applying Fourier analysis on curved and straight, A/T-type or G/C-type DNA sequence motifs. The best predictions were obtained with a new consensus bendability scale created by combining a nucleosome-based and a deoxyribonuclease I-based parameter set, Geometry calculations on the same sequences showed that the helical parameters derived from NMR structures can correctly predict curvature, as distinct from the parameters derived from X-ray crystallographic analysis.

引用

页码：65 / 68

页数：4

共 21 条

[1] AN ABINITIO MOLECULAR-ORBITAL STUDY ON THE SEQUENCE-DEPENDENCY OF DNA CONFORMATION - AN EVALUATION OF INTRA-STRAND AND INTER-STRAND STACKING INTERACTION ENERGY [J].