SEQUENCE-DEPENDENT BENDING PROPENSITY OF DNA AS REVEALED BY DNASE-I - PARAMETERS FOR TRINUCLEOTIDES

被引：254

作者：

BRUKNER, I

SANCHEZ, R

SUCK, D

PONGOR, S

机构：

[1] INT CTR GENET ENGN & BIOTECHNOL,I-34012 TRIESTE,ITALY

[2] EUROPEAN MOLEC BIOL LAB,DIV BIOL STRUCT & BIOCOMP,D-69012 HEIDELBERG,GERMANY

来源：

EMBO JOURNAL | 1995年 / 14卷 / 08期

关键词：

DNA CURVATURE; DNA FLEXIBILITY; DNA-PROTEIN INTERACTION; DNASE I; TRINUCLEOTIDES;

D O I：

10.1002/j.1460-2075.1995.tb07169.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Structural parameters characterizing the bending propensity of trinucleotides were deduced from DNase I digestion data using simple probabilistic models. In contrast to dinucleotide-based models of DNA bending and/or bendability, the trinucleotide parameters are in good agreement with X-ray crystallographic data on bent DNA. This improvement may be due to the fact that the trinucleotide model incorporates more sequence context information than do dinucleotide-based descriptions.

引用

页码：1812 / 1818

页数：7

共 38 条

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