Dendron-mediated self-assembly of highly PEGylated block copolymers: a modular nanocarrier platform

被引：45

作者：

Bae, Jin Woo ^{[2
]}

Pearson, Ryan M. ^{[2
]}

Patra, Niladri ^{[1
]}

Sunoqrot, Suhair ^{[2
]}

Vukovic, Lela ^{[1
]}

Kral, Petr ^{[1
]}

Hong, Seungpyo ^{[2
]}

机构：

[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

[2] Univ Illinois, Dept Biopharmaceut Sci, Chicago, IL 60612 USA

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 37期

基金：

美国国家科学基金会;

关键词：

DRUG-DELIVERY; AQUEOUS-SOLUTIONS; POLY(ETHYLENE GLYCOL); MICELLES; NANOPARTICLES; AMPHIPHILES; RELEASE;

D O I：

10.1039/c1cc14331j

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

PEGylated dendron coils (PDCs) were investigated as a novel potential nanocarrier platform. PDCs self-assembled into micelles at lower CMCs than linear copolymer counterparts by 1-2 orders of magnitude, due to the unique architecture of dendrons. MD simulations also supported thermodynamically favourable self-assembly mediated by dendrons.

引用

页码：10302 / 10304

页数：3

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