Cell apoptosis induced by carcinogenic metals

被引：102

作者：

Chen, F ^{[1
]}

Vallyathan, V ^{[1
]}

Castranova, V ^{[1
]}

Shi, L ^{[1
]}

机构：

[1] NIOSH, Hlth Effects Lab Div, Morgantown, WV 26505 USA

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2001年 / 222卷 / 1-2期

关键词：

apoptosis; metal; ROS; DNA damage; carcinogenesis;

D O I：

10.1023/A:1017970330982

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Well-documented evidence suggests that environmental and occupational exposure of toxic metals or metal-containing compounds can cause a number of human diseases, including inflammation and cancer, through DNA damage, protein modifications, or lipid peroxidation. This mini-review addresses the mechanisms of cell death induced by some carcinogenic metals, including arsenic (III), chromium (VI) and vanadium (V). A possible contribution of reactive oxygen species to metal-induced cell death is also discussed.

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页码：183 / 188

页数：6

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