Disorders of Bone Remodeling

被引：965

作者：

Feng, Xu ^{[1
,2
]}

McDonald, Jay M. ^{[1
,2
,3
]}

机构：

[1] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Ctr Metab Bone Dis, Birmingham, AL 35294 USA

[3] Vet Adm Med Ctr, Birmingham, AL 35233 USA

来源：

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 6 | 2011年 / 6卷

关键词：

osteoporosis; renal osteodystrophy; osteopetrosis; Paget's disease; rickets; TUMOR-NECROSIS-FACTOR; GROWTH-FACTOR-I; OSTEOCLAST DIFFERENTIATION FACTOR; MESENCHYMAL STEM-CELLS; TNF FAMILY-MEMBER; MINERAL DENSITY; POSTMENOPAUSAL OSTEOPOROSIS; OSTEOPROTEGERIN-LIGAND; ESTROGEN DEFICIENCY; CANCELLOUS BONE;

D O I：

10.1146/annurev-pathol-011110-130203

中图分类号：

R36 [病理学];

学科分类号：

100103 [病原生物学];

摘要：

The skeleton provides mechanical support for stature and locomotion, protects vital organs, and controls mineral homeostasis. A healthy skeleton must be maintained by constant bone modeling to carry out these crucial functions throughout life. Bone remodeling involves the removal of old or damaged bone by osteoclasts (bone resorption) and the subsequent replacement of new bone formed by osteoblasts (bone formation). Normal bone remodeling requires a tight coupling of bone resorption to bone formation to guarantee no alteration in bone mass or quality after each remodeling cycle. However, this important physiological process can be derailed by a variety of factors, including menopause-associated hormonal changes, age-related factors, changes in physical activity, drugs, and secondary diseases, which lead to the development of various bone disorders in both women and men. We review the major diseases of bone remodeling, emphasizing our current understanding of the underlying pathophysiological mechanisms.

引用

页码：121 / 145

页数：25

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