Cadherins and catenins in breast cancer

被引：301

作者：

Cowin, P

Rowlands, TM

Hatsell, SJ

机构：

[1] NYU, Sch Med, Dept Cell Biol, New York, NY 10016 USA

[2] NYU, Sch Med, Dept Dermatol, New York, NY 10016 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2005年 / 17卷 / 05期

关键词：

D O I：

10.1016/j.ceb.2005.08.014

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies show that cadherins and catenins are hormonally regulated and carry out physiological roles during mammary development but have pathological effects when deregulated. E-cadherin expression is irreversibly lost in invasive lobular breast cancer (ILC). Animal models of ILC provide mechanistic insight, confirming that E-cadherin serves as both a tumor suppressor and an invasion suppressor in ILC. Ductal breast cancer involves complex, reversible, epigenetic modulation of multiple cadherins. Transcriptional regulators of E-cadherin have been identified that induce epithelial-tomesenchymal transitions. Catenins are lost or mislocalized in tumors lacking cadherins. However, beta-catenin signaling is upregulated by numerous pathways in > 50% of breast tumors and animal models suggest its oncogenic function in breast relates to its role in mammary progenitor cell expansion.

引用

收藏

页码：499 / 508

页数：10

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