Extracellular matrix-based cancer targeting

被引：109

作者：

Karamanos, Nikos K. ^{[1
,2
]}

Piperigkou, Zoi ^{[1
,2
]}

Passi, Alberto ^{[3
]}

Gotte, Martin ^{[4
]}

Rousselle, Patricia ^{[5
]}

Vlodavsky, Israel ^{[6
]}

机构：

[1] Univ Patras, Dept Chem, Biochem Biochem Anal & Matrix Pathobiol Res Grp, Biochem Lab, Patras, Greece

[2] Inst Chem Engn Sci ICE HT, Fdn Res & Technol Hellas, Patras, Greece

[3] Univ Insubria, Dept Med & Surg, Varese, Italy

[4] Univ Hosp Munster, Dept Gynecol & Obstet, Munster, Germany

[5] Univ Lyon 1, Lab Biol Tissulaire & Ingn Therapeu, UMR 5305, SFR BioSci Gerland Lyon Sud,CNRS, Lyon, France

[6] Technion Integrated Canc Ctr, Rappaport Fac Med, Haifa, Israel

来源：

TRENDS IN MOLECULAR MEDICINE | 2021年 / 27卷 / 10期

基金：

以色列科学基金会;

关键词：

ESTROGEN-RECEPTOR BETA; HEPARAN-SULFATE; TUMOR-GROWTH; CELLS; PROTEOGLYCANS; REGULATORS; EXOSOMES; DOMAIN; HEAD; PROGRESSION;

D O I：

10.1016/j.molmed.2021.07.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Tumor extracellular matrix (ECM) operates in a coordinated mode with cancer and stroma cells to evoke the multistep process of metastatic potential. The remodeled tumor-associated matrix provides a point for direct or complemen-tary therapeutic targeting. Here, we cover and critically address the importance of ECM networks and their macromolecules in cancer. We focus on the roles of key structural and functional ECM components, and their degradation enzymes and extracellular vesicles, aiming at improving our understanding of the mecha-nisms contributing to tumor initiation, growth, and dissemination, and discuss potential new approaches for ECM-based therapeutic targeting and diagnosis.

引用

收藏

页码：1000 / 1013

页数：14

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