BDNF/TRKB/P75NTR polymorphisms and their consequences on antidepressant efficacy in depressed patients

被引：34

作者：

Colle, Romain ^{[1
]}

Deflesselle, Eric ^{[1
]}

Martin, Severine ^{[1
]}

David, Denis J. ^{[2
]}

Hardy, Patrick ^{[1
]}

Taranu, Adela ^{[1
]}

Falissard, Bruno ^{[3
]}

Verstuyft, Celine ^{[4
,5
]}

Corruble, Emmanuelle ^{[1
]}

机构：

[1] Hop Bicetre, AP HP, INSERM UMR Team Depress & Antidepressants 1178, Fac Med Paris Sud,Serv Psychiat, F-94275 Le Kremlin Bicetre, France

[2] Fac Pharm Paris, INSERM UMR Team Depress & Antidepressants 1178, Chatenay Malabry, France

[3] Hop Paul Brousse, AP HP, INSERM UMR 1178, Fac Med Paris Sud,Dept Biostat, F-94400 Villejuif, France

[4] Univ Paris 11, Hop Bicetre, AP HP,Serv Genet Mol Pharmacogenet & Hormonol, INSERM Immunol Malad Virales & Autoimmues, F-94275 Le Kremlin Bicetre, France

[5] Univ Paris 11, INSERM U1184, F-92296 Chatenay Malabry, France

来源：

PHARMACOGENOMICS | 2015年 / 16卷 / 09期

关键词：

antidepressant remission; antidepressant response; BDNF; major depressive disorder; major depressive episode; PNTR75; single nucleotide polymorphism; TRKB; NEUROTROPHIC FACTOR GENE; GENOME-WIDE ASSOCIATION; VAL66MET POLYMORPHISM; MAJOR DEPRESSION; FACTOR BDNF; TREATMENT RESPONSE; GLUCOCORTICOID-RECEPTOR; SEROTONIN TRANSPORTER; SEQUENCE VARIATIONS; BRAIN;

D O I：

10.2217/pgs.15.56

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We propose an extensive review of the literature about BDNF/TRKB/P75NTR polymorphisms and their consequences on antidepressant efficacy in depressed patients. Five genome-wide association studies and 30 association studies were included. Twenty seven studies focused on the Val66Met polymorphism (rs6265), the Met allele being associated with a higher antidepressant efficacy only in Asian patients. Other BDNF/TRKB/P75NTR polymorphisms (BDNF: rs7103411, rs7124442, rs908867, rs2049046, rs61888800, rs10501087, rs1491850; TRKB: rs10868223, rs11140778, rs1565445, rs1659412; P75NTR: rs2072446) were reported to be associated with antidepressant efficacy but these results were not replicated. Finally, there are 15 positive studies among 30 studies regarding BDNF/TRKB/P75NTR polymorphisms. The only SNP which benefits of at least three positive studies is the BDNF Val66Met polymorphism (rs6265). Consequently, with a lack of good and consistent studies, the clinical utility of BDNF in treatment selection is far from clear. We propose several recommendations for further studies.

引用

页码：997 / 1013

页数：17

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