Mapping the new frontier: complex genetic disorders

被引:37
作者
Mayeux, R
机构
[1] Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10032 USA
[2] Columbia Univ, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10032 USA
关键词
D O I
10.1172/JCI25421
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The remarkable achievements in human genetics over the years have been clue to technological advances in gene mapping and in statistical methods that relate genetic variants to disease. Nearly every Mendelian genetic disorder has now been mapped to a specific gene or set of genes, but these discoveries have been limited to high-risk, variant alleles that segregate in rare families. With a working draft of the human genome now in hand, the availability of high-throughput genotyping, a plethora of genetic markers, and the development of new analytical methods, scientists are now turning their attention to common complex disorders such as diabetes, obesity, hypertension, and Alzheimer disease. In this issue, the JCI provides readers with a series dedicated to complex genetic disorders, offering a view of genetic medicine in the 21st century.
引用
收藏
页码:1404 / 1407
页数:4
相关论文
共 15 条
[1]   The genetic epidemidogy of neurodegenerative disease [J].
Bertram, L ;
Tanzi, RE .
JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (06) :1449-1457
[2]  
Falconer D. S., 1989, Introduction to quantitative genetics.
[3]   Factors affecting statistical power in the detection of genetic association [J].
Gordon, D ;
Finch, SJ .
JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (06) :1408-1418
[4]  
GRILO CM, 1991, PSYCHOL BULL, V110, P520
[5]   Genome-wide association studies for common diseases and complex traits [J].
Hirschhorn, JN ;
Daly, MJ .
NATURE REVIEWS GENETICS, 2005, 6 (02) :95-108
[6]  
Khoury MJ., 1993, FUNDAMENTALS GENETIC
[7]   Finding schizophrenia genes [J].
Kirov, G ;
O'Donovan, MC ;
Owen, MJ .
JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (06) :1440-1448
[8]   GENETIC DISSECTION OF COMPLEX TRAITS [J].
LANDER, ES ;
SCHORK, NJ .
SCIENCE, 1994, 265 (5181) :2037-2048
[9]   Mapping quantitative trait loci in humans: achievements and limitations [J].
Majumder, PP ;
Ghosh, S .
JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (06) :1419-1424
[10]   Linkage disequilibrium maps and association mapping [J].
Morton, NE .
JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (06) :1425-1430