A human putative Suv3-like RNA helicase is conserved between Rhodobacter and all eukaryotes

被引：41

作者：

Dmochowska, A

Kalita, K

Krawczyk, M

Golik, P

Mroczek, K

Lazowska, J

Stepien, PP

Bartnik, E ^{[1
]}

机构：

[1] Univ Warsaw, Dept Genet, Warsaw, Poland

[2] Polish Acad Sci, Inst Biochem & Biophys, PL-02106 Warsaw, Poland

[3] CNRS, Ctr Genet Mol, F-91198 Gif Sur Yvette, France

来源：

ACTA BIOCHIMICA POLONICA | 1999年 / 46卷 / 01期

关键词：

human; S-cerevisiae; RNA helicase; SUPV3L1; SUV3;

D O I：

10.18388/abp.1999_4193

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have cloned and sequenced a cDNA of the human homologue of the Saccharomyces cerevisiae Suv3 putative RNA helicase which is indispensable for mitochondrial function in yeast. The human Suv-3-like protein has a typical mitochondrial leader sequence. Northern blot data and analysis of ESTs in the data banks indicate that this human gene (SUPV3L1) is expressed in practically all tissues, though at different levels. Sequence homology analysis has shown a strong conservation of the protein in a number of eukaryotic organisms - plants, mammals and fungi, but no close homologues exist in bacteria with the exception of the purple bacterium Rhodobacter sphaeroides. This gene is thus ubiquitously present in all eukaryotic organisms.

引用

页码：155 / 162

页数：8