Coordinate regulation of metabotropic glutamate receptors

被引：72

作者：

Alagarsamy, S

Sorensen, SD

Conn, PJ

机构：

[1] Emory Univ, Dept Pharmacol, Rollins Res Ctr, Atlanta, GA 30322 USA

[2] Merck & Co Inc, Merck Res Labs, Neurosci, West Point, PA 19486 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2001年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0959-4388(00)00219-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent studies aimed at identifying the mechanisms that regulate the signaling of metabotropic glutamate receptors (mGluRs) have revealed that both protein kinase and protein phosphatase activity are important in directly modulating mGluR function. The inter-relationship between phosphorylation and dephosphorylation of mGluRs seems to be an important determinant in regulating mGluR function and the subsequent neuromodulatory events elicited by activation of mGluRs.

引用

页码：357 / 362

页数：6

共 60 条

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