Host factors involved in retroviral budding and release

被引：147

作者：

Martin-Serrano, Juan ^{[1
]}

Neil, Stuart J. D. ^{[1
]}

机构：

[1] Guys Hosp, Dept Infect Dis, London SE1 9RT, England

来源：

NATURE REVIEWS MICROBIOLOGY | 2011年 / 9卷 / 07期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; NUCLEAR EXPORT ELEMENTS; TO-CELL TRANSMISSION; ESCRT-III; LATE-DOMAIN; PLASMA-MEMBRANE; STRUCTURAL BASIS; PARTICLE RELEASE; TERMINAL DOMAIN; INHIBITS HIV-1;

D O I：

10.1038/nrmicro2596

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The plasma membrane is the final barrier that enveloped viruses must cross during their egress from the infected cell. Here, we review recent insights into the cell biology of retroviral assembly and release; these insights have driven a new understanding of the host proteins, such as the ESCRT machinery, that are used by retroviruses to promote their final separation from the host cell. We also review antiviral host factors such as tetherin, which can directly inhibit the release of retroviral particles. These studies have illuminated the role of the lipid bilayer as the unexpected target for virus restriction by the innate immune response.

引用

页码：519 / 531

页数：13

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