Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

被引：256

作者：

Cao, Wei ^{[1
]}

Bover, Laura ^{[1
]}

Cho, Minkwon ^{[3
]}

Wen, Xiaoxia ^{[2
]}

Hanabuchi, Shino ^{[1
]}

Bao, Musheng ^{[1
]}

Rosen, David B. ^{[4
,5
]}

Wang, Yi-Hong ^{[1
]}

Shaw, Joanne L. ^{[1
]}

Du, Qiumei ^{[1
]}

Li, Chun ^{[2
]}

Arai, Naoko

Yao, Zhengbin ^{[6
]}

Lanier, Lewis L. ^{[4
,5
]}

Liu, Yong-Jun ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77054 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Expt Diagnost Imaging, Houston, TX 77054 USA

[3] SBI Biotech Co Ltd, Ginkgo Biomed Res Inst, Kawasaki, Kanagawa 2160001, Japan

[4] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Canc Res Inst, San Francisco, CA 94143 USA

[6] Genentech Inc, San Francisco, CA 94080 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2009年 / 206卷 / 07期

基金：

美国国家卫生研究院;

关键词：

TOLL-LIKE RECEPTORS; INTERFERON-PRODUCING CELLS; NKG2D RECEPTOR; T-CELLS; ACTIVATING RECEPTOR; IMMUNE-COMPLEXES; CUTTING EDGE; I INTERFERON; NK CELLS; LIGAND;

D O I：

10.1084/jem.20090547

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasmacytoid dendritic cells (pDCs) produce copious type I interferon (IFN) upon sensing nucleic acids through Toll-like receptor (TLR) 7 and TLR9. Uncontrolled pDC activation and IFN production are implicated in lymphopenia and autoimmune diseases; therefore, a mechanism controlling pDC IFN production is essential. Human pDCs specifically express an orphan receptor, immunoglobulin-like transcript 7 (ILT7). Here, we discovered an ILT7 ligand expressed by human cell lines and identified it as bone marrow stromal cell antigen 2 (BST2; CD317). BST2 directly binds to purified ILT7 protein, initiates signaling via the ILT7-Fc epsilon RI gamma complex, and strongly inhibits production of IFN and proinflammatory cytokines by pDCs. Readily induced by IFN and other proinflammatory cytokines, BST2 may modulate the human pDC's IFN responses through ILT7 in a negative feedback fashion.

引用

页码：1603 / 1614

页数：12

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