Nickel-catalyzed asymmetric Negishi cross-couplings of secondary allylic chlorides with alkylzincs

被引：195

作者：

Son, Sunghee ^{[1
]}

Fu, Gregory C. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 09期

关键词：

D O I：

10.1021/ja800103z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Complementing previous advances in allylation chemistry, an effective nickel/Pybox catalyst for regioselective asymmetric Negishi cross-couplings of racemic secondary allylic chlorides with readily available organozinc halides has been developed. The method has been applied in two key steps of a formal total synthesis of fluvirucinine A(1).

引用

页码：2756 / +

页数：3

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