Stereoselective total synthesis of (+)-norrisolide

被引：57

作者：

Brady, TP ^{[1
]}

Kim, SH ^{[1
]}

Wen, K ^{[1
]}

Theodorakis, EA ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 06期

关键词：

D O I：

10.1002/anie.200352868

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In a convergent approach to the marine natural product (+)-norrisolide (1) the two bicyclic ring systems are coupled through the C9-C10 bond to assemble the carbon framework in a late stage of the synthesis. Other highlights of the synthetic strategy include the formation of the unusual fused γ-lactone-γ-lactol motif of 1 through a sequence of oxidation reactions.

引用

页码：739 / 742

页数：4

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