Synthesis and cytotoxic activity of novel C7-functionalized spongiane diterpenes

被引：27

作者：

Arnó, M

Betancur-Galvis, L ^{[1
]}

González, MA

Sierra, J

Zaragozá, RJ

机构：

[1] Univ Valencia, Dept Quim Organ, E-46100 Burjassot, Valencia, Spain

[2] Univ Antioquia, Grp Infecc & Canc, Medellin, Colombia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 14期

关键词：

D O I：

10.1016/S0968-0896(03)00230-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Based on two lead cytotoxic spongiane diterpenes, a new series of C7-oxygenated derivatives were synthesized and evaluated for their antitumor activity in vitro against the cancer cell lines HeLa and HEp-2. In general, introduction of either hvdroxyl or acetoxy groups at C-7 did not improve the resultant cytotoxicity, while the presence of a butyrate ester led to more active compounds (CC50 = 4.0-9.5 muM). (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：3171 / 3177

页数：7

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