Cytotoxic effect (on tumor cells) and in vitro antiviral activity against herpes simplex virus of synthetic spongiane diterpenes

被引：33

作者：

Betancur-Galvis, L ^{[1
]}

Zuluaga, C

Arnó, M

González, MA

Zaragozá, RJ

机构：

[1] Univ Antioquia, Grp Inmunovirol Biogenesis, Medellin 1226, Colombia

[2] Univ Valencia, Dept Quim Organ, E-46100 Valencia, Spain

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 02期

关键词：

D O I：

10.1021/np010206t

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A series of synthetic spongiane-type diterpenes have been tested in vitro for their potential antitumor and antiherpetic activity. Although the antiviral activity of these compounds against herpes simplex virus type 2 (HSV-2) was very weak, some compounds exhibited relevant cytotoxicity in the human tumor cell lines HeLa and HEp-2. The biological activity of formyl spongianes is reported for the first time. With the present study, some structure-activity trends are suggested for the cytotoxic activity of these sponge-derived natural products.

引用

页码：189 / 192

页数：4

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