SYNTHESIS AND IN-VITRO CYTOTOXICITY OF (+/-)-ACETOMYCIN AND RELATED ANALOGS

被引：9

作者：

CHEN, D ^{[1
]}

SPRULES, TJ ^{[1
]}

LAVALLEE, JF ^{[1
]}

机构：

[1] BIOCHEM THERAPEUT INC,LAVAL,PQ H7V 4A7,CANADA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 07期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/0960-894X(95)00110-F

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(+/-)-Acetomycin and related analogs were synthesized and evaluated for their cytotoxic activity against B16 mouse melanoma cells, DA-3 mouse mammary adenocarcinoma cells, HT-29 human breast adenocarcinoma cells and MCF7-WT human colon adenocarcinoma cells. Blood stability assays were also performed on some of these products.

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页码：759 / 762

页数：4

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