Semicarbazide-functionalized Si(111) surfaces for the site-specific immobilization of peptides

被引：46

作者：

Coffinier, Y

Olivier, C

Perzyna, A

Grandidier, B

Wallart, X

Durand, JO

Melnyk, O

Stiévenard, D

机构：

[1] IEMN, CNRS, UMR 8520, Dept ISEN, F-59046 Lille, France

[2] Univ Montpellier 2, CNRS, UMR 5637, F-34095 Montpellier 05, France

[3] Biol Inst Lille, CNRS, UMR 8525, F-59021 Lille, France

来源：

LANGMUIR | 2005年 / 21卷 / 04期

关键词：

D O I：

10.1021/la047781s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The covalent attachment of semicarbazide-functionalized layers to hydrogen-terminated Si(111) surfaces is reported. The surface modification, based on the photoinduced hydrosilylation of a Si(111) surface with protected semicarbazide-functionalized alkenes, was investigated by means of X-ray photoelectron spectroscopy (XPS), contact angle measurements, and atomic force microscopy (AFM). The removal of the protecting group yielded a semicarbazide-terminated monolayer which was reacted with peptides bearing a glyoxylyl group for site-specific alpha-oxo semicarbazone ligation.

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页码：1489 / 1496

页数：8

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