Tumour stem cells and drug resistance

被引：3018

作者：

Dean, M ^{[1
]}

Fojo, T

Bates, S

机构：

[1] NCI, Lab Genom Divers, Frederick, MD 21702 USA

[2] NCI, Canc Therapeut Branch, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 04期

关键词：

D O I：

10.1038/nrc1590

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The contribution of tumorigenic stem cells to haematopoietic cancers has been established for some time, and cells possessing stem-cell properties have been described in several solid tumours. Although chemotherapy kills most cells in a tumour, it is believed to leave tumour stem cells behind, which might be an important mechanism of resistance. For example, the ATP-binding cassette (ABC) drug transporters have been shown to protect cancer stem cells from chemotherapeutic agents. Gaining a better insight into the mechanisms of stem-cell resistance to chemotherapy might therefore lead to new therapeutic targets and better anticancer strategies.

引用

收藏

页码：275 / 284

页数：10

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