Human adipose tissue-derived mesenchymal stromal cells as salvage therapy for treatment of severe refractory acute graft-vs.-host disease in two children

被引：94

作者：

Fang, Baijun

Song, Yongping

Lin, Quande

Zhang, Yanli

Cao, Ying

Zhao, Robert Chunhua

Ma, Yuanfang

机构：

[1] Henan Tumor Hosp, Inst Haematol, Zhengzhou 450008, Peoples R China

[2] Chinese Acad Med Sci, Inst Basic Med Sci, Ctr Excellence Tissue Engn, Beijing 100730, Peoples R China

[3] Chinese Acad Med Sci, Sch Basic Med, Beijing 100730, Peoples R China

[4] Peking Union Med Coll, Beijing, Peoples R China

[5] Henan Univ, Inst Immunol, Cellular & Mol Immunol Lab, Kaifeng, Peoples R China

来源：

PEDIATRIC TRANSPLANTATION | 2007年 / 11卷 / 07期

关键词：

hematopoietic stem cell transplantation; graft-vs.-host disease; mesenchymal stromal cell; adipose tissue;

D O I：

10.1111/j.1399-3046.2007.00780.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Severe GVHD is a lethal complication to ASCT, and a number of approaches are therefore being evaluated. Recently, Le Blanc et al. reported a case of grade IV therapy-resistant acute GVHD of the gut and liver that showed rapid improvement after infusion of mesenchymal stem cells. Here we describe two pediatric patients who developed severe refractory acute GVHD following ASCT and were successfully treated with AMSC from HLA-mismatched unrelated donors.

引用

收藏

页码：814 / 817

页数：4

相关论文

共 24 条

[1]

Abhyankar S, 1998, BLOOD, V92, p340B

[2] HIGH-DOSE BOLUS METHYLPREDNISOLONE FOR THE TREATMENT OF ACUTE GRAFT VERSUS HOST-DISEASE [J].

BACIGALUPO, A ;

VANLINT, MT ;

FRASSONI, F ;

PODESTA, M ;

VENEZIANO, G ;

AVANZI, G ;

VITALE, V ;

MARMONT, AM .

BLUT, 1983, 46 (03) :125-132

[3] Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo [J].

Bartholomew, A ;

Sturgeon, C ;

Siatskas, M ;

Ferrer, K ;

McIntosh, K ;

Patil, S ;

Hardy, W ;

Devine, S ;

Ucker, D ;

Deans, R ;

Moseley, A ;

Hoffman, R .

EXPERIMENTAL HEMATOLOGY, 2002, 30 (01) :42-48

[4] Sirolimus (rapamycin) for the treatment of steroid-refractory acute graft-versus-host disease [J].

Benito, AI ;

Furlong, T ;

Martin, PJ ;

Anasetti, C ;

Appelbaum, FR ;

Doney, K ;

Nash, RA ;

Papayannopoulou, T ;

Storb, R ;

Sullivan, KM ;

Witherspoon, R ;

Deeg, HJ .

TRANSPLANTATION, 2001, 72 (12) :1924-1929

[5] Homing of in vitro expanded Stro-1- or Stro-1+ human mesenchymal stem cells into the NOD/SCID mouse and their role in supporting human CD34 cell engraftment [J].

Bensidhoum, M ;

Chapel, A ;

Francois, S ;

Demarquay, C ;

Mazurier, C ;

Fouillard, L ;

Bouchet, S ;

Bertho, JM ;

Gourmelon, P ;

Aigueperse, J ;

Charbord, P ;

Gorin, NC ;

Thierry, D ;

Lopez, M .

BLOOD, 2004, 103 (09) :3313-3319

[6] Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo [J].

Cao, Y ;

Sun, Z ;

Liao, LM ;

Meng, Y ;

Han, Q ;

Zhao, RCH .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 332 (02) :370-379

[7] Mesenchymal stem cells in immunoregulation [J].

Chen, Xi ;

Armstrong, Marilyn Ann ;

Li, Gang .

IMMUNOLOGY AND CELL BIOLOGY, 2006, 84 (05) :413-421

[8] Allogeneic bone marrow-derived flk-1+Sca-1- mesenchymal stem cells leads to stable mixed chimerism and donor-specific tolerance [J].

Deng, WM ;

Han, Q ;

Liao, LM ;

Li, CH ;

Ge, W ;

Zhao, ZG ;

You, SG ;

Deng, HY ;

Zhao, RCH .

EXPERIMENTAL HEMATOLOGY, 2004, 32 (09) :861-867

[9] Treatment of severe therapy-resistant acute graft-versus-host disease with human adipose tissue-derived mesenchymal stem cells [J].

Fang, B. ;

Song, Y. P. ;

Liao, L. M. ;

Han, Q. ;

Zhao, R. C. .

BONE MARROW TRANSPLANTATION, 2006, 38 (05) :389-390

[10] Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone [J].

Horwitz, EM ;

Gordon, PL ;

Koo, WKK ;

Marx, JC ;

Neel, MD ;

McNall, RY ;

Muul, L ;

Hofmann, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (13) :8932-8937