Preparation of Multifunctional Polymeric Micelles for Antiviral Treatment

被引：12

作者：

Ahn, Yong Sik ^{[1
]}

Baik, Hye Jung ^{[1
]}

Lee, Bo Reum ^{[1
]}

Lee, Eun Seong ^{[1
]}

Oh, Kyung Taek ^{[2
]}

Lee, Don Haeng ^{[3
]}

Youn, Yu Seok ^{[4
]}

机构：

[1] Catholic Univ Korea, Div Biotechnol, Gyeonggi Do 420743, South Korea

[2] Chung Ang Univ, Coll Pharm, Seoul 155756, South Korea

[3] Inha Univ, Dept Internal Med, Inchon 402751, South Korea

[4] Pusan Natl Univ, Coll Pharm, Pusan 609735, South Korea

来源：

MACROMOLECULAR RESEARCH | 2010年 / 18卷 / 08期

关键词：

polymeric micelle; sialic acid; multifunctionality; antiviral; IN-VITRO; TUMOR; HEMAGGLUTININ; LIGANDS; BINDING; ACIDS;

D O I：

10.1007/s13233-010-0802-8

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

In this study, a poly(L-lactic acid)-b-poly(ethylene glycol) (PLLA-b-PEG) diblock copolymer modified with a sialic acid derivative (methyl-b-neuraminic acid: mNA) was prepared for the development and application of a therapeutic nanosystem with multifunctionality. The terminal carboxyl group of PEG was coupled with mNA via N,N'-dicyclohexyl carbodiimide (DCC)- and N-hydroxysuccinimide (NHS)-mediated amide formation. Polymeric micelles were formed using the diafilteration method at pH 7.4, which resulted in a micelle self-assembly with the PLLA block at the core and PEG-mNA block on the shell. An anionic charge was formed on the surface of the micelle at physiological pH (similar to pH 7.4) due to mNA. Amantadine (AMT), a model drug for antiviral treatment, was loaded into the micellar core. These micelles were expected to exhibit multiple therapeutic activity that originated from the antiviral activity of mNA on the shell and the sustained release of AMT from the micellar core.

引用

页码：747 / 752

页数：6

共 27 条

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