Increased soluble TNF receptor 2 in antidepressant-free patients with late-life depression

被引：46

作者：

Diniz, Breno Satler ^{[1
]}

Teixeira, Antonio Lucio ^{[2
,3
]}

Talib, Leda Leme ^{[1
]}

Mendonca, Vanessa Amaral ^{[2
,3
]}

Gattaz, Wagner Farid ^{[1
]}

Forlenza, Orestes Vicente ^{[1
]}

机构：

[1] Univ Sao Paulo, Lab Neurosci LIM 27, Dept & Inst Psychiat, Fac Med, BR-05403010 Sao Paulo, Brazil

[2] Univ Fed Minas Gerais, Grp Neuroimmunol, Lab Immunopharmachol, Inst Biol Sci, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Sch Med, Belo Horizonte, MG, Brazil

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 2010年 / 44卷 / 14期

基金：

巴西圣保罗研究基金会;

关键词：

Late-life depression; Early-onset depression; Tumor necrosis factor alpha; Tumor necrosis factor alpha soluble receptor; Pathophysiology; MILD COGNITIVE IMPAIRMENT; INFLAMMATORY MARKERS; ALPHA RECEPTORS; DEMENTIA; DIAGNOSIS; DISORDER; DISEASE; PEOPLE; HEALTH; SERUM;

D O I：

10.1016/j.jpsychires.2010.02.008

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Increased pro-inflammatory state has been implicated in the pathophysiology of major depressive disorder. The aim of this study was to determine serum levels of INF-alpha and soluble TNF-alpha receptors 1 and 2 (sTNFR1 and sTNFR2) in anti-depressant free depressed elderly patients as compared to healthy controls. Sixty-seven older adults (28 with major depression and 39 controls) were enrolled to this study. Participants were assessed by the SCID and diagnosis of major depressive episode was made according to the DSM-IV criteria. Serum INF-alpha, 5TNFR1 and sTNFR2 were determined by ELISA. Anti-depressant free patients with late-life depression showed an increased level of the sTNFR2 as compared to controls (p = 0.03). No significant differences were found in serum INF-alpha and sTNFR1 levels (p = 0.1 and p = 0.4, respectively). There was no correlation between serum levels of these inflammatory markers and the severity of depression. Our findings provide additional evidence of the involvement of abnormal pro-inflammatory state in late-life depression. (c) 2010 Elsevier Ltd. All rights reserved.

引用

页码：917 / 920

页数：4

共 29 条

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