High spatial resolution imaging mass spectrometry and classical histology on a single tissue section

被引：84

作者：

Deutskens, Fabian ^{[1
]}

Yang, Junhai ^{[1
]}

Caprioli, Richard M. ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Biochem, Mass Spectrometry Res Ctr, Nashville, TN 37232 USA

来源：

JOURNAL OF MASS SPECTROMETRY | 2011年 / 46卷 / 06期

关键词：

MALDI-MS; imaging mass spectrometry; histology; high resolution; tissue; protein; MALDI; PEPTIDES; PROTEINS; MS;

D O I：

10.1002/jms.1926

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The work presented in this report describes and demonstrates a protocol for protein imaging analysis of biological tissue using MALDI IMS where histological staining and MS analysis are performed on the same tissue section. Spatial image resolution is shown at 35 mu m for sagittal sections of the cerebellum from rat brain. Copyright (C) 2011 John Wiley & Sons, Ltd.

引用

页码：568 / 571

页数：4

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