Genetic epidemiology of diabetes

被引：183

作者：

Permutt, MA

Wasson, J

Cox, N

机构：

[1] Washington Univ, Sch Med, Dept Endocrinol Metab & Lipid Res, St Louis, MO 63110 USA

[2] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 06期

关键词：

D O I：

10.1172/JCI24758

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Conventional genetic analysis focuses on the genes that account for specific phenotypes, while traditional epidemiology is more concerned with the environmental causes and risk factors related to traits. Genetic epidemiology is an alliance of the 2 fields that focuses on both genetics, including allelic variants in different populations, and environment, in order to explain exactly how genes convey effects in different environmental contexts and to arrive at a more complete comprehension of the etiology of complex traits. In this review, we discuss the epidemiology of diabetes and the current understanding of the genetic bases of obesity and diabetes and provide suggestions for accelerated accumulation of clinically useful genetic information.

引用

页码：1431 / 1439

页数：9

共 117 条

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