Effect of smoking on ovarian reserve and ovarian stimulation in in-vitro fertilization and embryo transfer

被引:102
作者
El-Nemr, A
Al-Shawaf, T
Sabatini, L
Wilson, C
Lower, AM
Grudzinskas, JG [1 ]
机构
[1] Univ London St Bartholomews Hosp Med Coll, Royal Hosp NHS Trust, Fertil Ctr, London EC1A 7BE, England
[2] Royal London Hosp, St Bartholomews & Royal London Sch Med & Dent, Acad Dept Obstet & Gynaecol, London E1 1BB, England
关键词
follicle stimulating hormone; IVF; ovarian reserve; ovulation induction; smoking;
D O I
10.1093/humrep/13.8.2192
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The effect of cigarette smoking on ovarian reserve as measured by basal serum follicle stimulating hormone (FSH) concentrations, and by the response to a standard ovarian stimulation protocol, was examined retrospectively in 173 consecutive women (108 non-smokers and 65 smokers) undergoing in-vitro fertilization (IVF) and embryo transfer treatment. Women who smoked had a higher mean basal serum FSH concentration (P less than or equal to 0.0001), in particular younger (<36 years) women, and required a statistically significantly higher mean dosage of gonadotrophins for ovarian stimulation than the non-smokers (48.1 +/- 15.6 versus 38.9 +/- 13.6 ampoules, 75 IU/ampoule; P < 0.0001), A lower mean number of oocytes was obtained in smokers than non-smokers (6.2 +/- 3.4 versus 11.1 +/- 6.3, oocytes P less than or equal to 0.0001) and the rate of abandoned cycles (18.5 versus 8.5%) and total fertilization failure (18.5 versus 8.5%) was higher. The clinical pregnancy rate per cycle in smokers was 16.9% versus 21.3% in non-smokers but this was not statistically significant. In conclusion, cigarette smoking in women appears to significantly reduce their ovarian reserve and lead to poor response to ovarian stimulation at an earlier age.
引用
收藏
页码:2192 / 2198
页数:7
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