The role of laminin in embryonic cell polarization and tissue organization

被引：232

作者：

Li, SH

Edgar, D

Fässler, R

Wadsworth, W

Yurchenco, PD ^{[1
]}

机构：

[1] Robert Wood Johnson Med Sch, Dept Pathol & Lab Med, Piscataway, NJ 08854 USA

[2] Univ Liverpool, Dept Human Anat & Cell Biol, Liverpool L69 3G3E, Merseyside, England

[3] Max Planck Inst Biochem, Dept Mol Med, D-82152 Martinsried, Germany

来源：

DEVELOPMENTAL CELL | 2003年 / 4卷 / 05期

关键词：

D O I：

10.1016/S1534-5807(03)00128-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genetic analyses have revealed that members of the laminin glycoprotein family are required for basement membrane assembly and cell polarization, with subsequent effects on cell survival and tissue organization during metazoan embryogenesis. These functions depend upon the cooperation between laminin polymerization and cell anchorage mediated via interactions with beta1-integrins, dystroglycan, and other cell surface receptors.

引用

页码：613 / 624

页数：12

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