Annomolin and annocherimolin, new cytotoxic annonaceous acetogenins from Annona cherimolia seeds

被引：29

作者：

Kim, DH

Ma, FS

Suk, KD

Son, JK

Lee, JS

Woo, MH ^{[1
]}

机构：

[1] Catholic Univ Daegu, Coll Pharm, Dept Pharm, Gyeongsan 712702, South Korea

[2] Yeungnam Univ, Coll Pharm, Dept Pharm, Kyongsan 712749, South Korea

[3] Yeungnam Univ, Coll Sci, Dept Biochem, Kyongsan 712749, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 04期

关键词：

D O I：

10.1021/np000335u

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new cytotoxic annonaceous acetogenins, annomolin (1) and annocherimolin (2), were isolated from an ethanolic extract of the seeds of Annena cherimelia. Annomolin has a mono-THF ring with one flanking hydroxyl and possesses a 1,2-diol at C-7/8 of the aliphatic chain. Annocherimolin has a mono-THF ring with two flanking hydroxyls and possesses a double bond at C-21/22. Their structures were elucidated by spectral data and chemical derivatization. Compound 1 showed cytotoxic selectivity for the human prostate tumor cell line (PC-3), with a potency of over 10 000 times that of adriamycin. Compound 2 showed cytotoxic potencies about 10 000 times those of adriamycin in the breast (MCF-7) and colon (HT-29) cancer cell lines.

引用

收藏

页码：502 / 506

页数：5

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