Biological role of the CCAAT enhancer-binding protein family of transcription factors

被引：686

作者：

Lekstrom-Himes, J ^{[1
]}

Xanthopoulos, KG ^{[1
]}

机构：

[1] Natl Human Genome Res Inst, Clin Gene Therapy Branch, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1998年 / 273卷 / 44期

关键词：

D O I：

10.1074/jbc.273.44.28545

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CCAAT/enhancer-binding proteins (C/EBPs) comprise a family of transcription factors that are critical for normal cellular differentiation and function in a variety of tissues. The prototypic C/EBP is a modular protein, consisting of an activation domain, a dimerization bZIP region, and a DNA binding domain. All family members share the highly conserved dimerization domain, required for DNA binding, by which they form homo- and heterodimers with other family members. C/EBPs are least conserved in their activation domains and vary from strong activators to dominant negative repressors. The pleiotropic effects of C/EBPs are in part because of tissue- and stage-specific expression. Dimerization of different C/EBP proteins precisely modulates transcriptional activity of target genes, Recent work with mice deficient in specific C/EBPs underscores the effects of these factors in tissue development, function, and response to injury.

引用

页码：28545 / 28548

页数：4

共 86 条

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