Synthesis of chiral amino allenes via an organocyanocuprate-mediated ring-opening reaction of enantiopure ethynylaziridines

被引：37

作者：

Ohno, H ^{[1
]}

Toda, A ^{[1
]}

Miwa, Y ^{[1
]}

Taga, T ^{[1
]}

Fujii, N ^{[1
]}

Ibuka, T ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 02期

关键词：

D O I：

10.1016/S0040-4039(98)02348-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Amino allenes have been synthesized from 2-ethynylaziridines via organocopper-mediated reactions. Whereas treatment of enantiomerically pure (2R,3S)-2,3-trans-3-alkyl-2-ethynylaziridines with RCu(CN)M (M = Li or MgX) yield exclusively (S,S)-allenylamines in high yields, isomeric (2S,3S)-2,3-cis-3-alkyl-2-ethynylaziridines afford (S,R)-allenylamines in comparable high yields. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：349 / 352

页数：4