Proline-modified poly (propyleneimine) dendrimers as catalysts for asymmetric aldol reactions

被引：56

作者：

Bellis, E ^{[1
]}

Kokotos, G ^{[1
]}

机构：

[1] Univ Athens, Dept Chem, Organ Chem Lab, GR-15771 Athens, Greece

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2005年 / 241卷 / 1-2期

关键词：

aldol reactions; asymmetric catalysis; dendrimers; organocatalysis; proline;

D O I：

10.1016/j.molcata.2005.05.047

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A series of surface-functionalized poly(propyleneimine) dendrimers (five generations) based on proline were synthesized and were evaluated as catalysts for asymmetric aldol reactions. Using 6.5 mol% of the second generation modified dendrimer as catalyst, the products of the aldol reactions were obtained in yields and and ee's comparable to those observed using proline itself, in much less reaction time (2h) in comparison to that required for proline (16-18 h). In addition, the improved solubility of dendritic catalysts in organic solvents provides completely homogeneous reaction mixtures. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：166 / 174

页数：9

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