Synaptic Integration Gradients in Single Cortical Pyramidal Cell Dendrites

被引:234
作者
Branco, Tiago [1 ,2 ]
Haeusser, Michael [1 ,2 ]
机构
[1] UCL, Wolfson Inst Biomed Res, London WC1E 6BT, England
[2] UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England
基金
英国惠康基金;
关键词
LOCATION-DEPENDENT VARIABILITY; BASAL DENDRITES; ACTION-POTENTIALS; ACTIVE DENDRITES; VISUAL-CORTEX; NEURONS; DISTAL; RAT; PLASTICITY; EPSP;
D O I
10.1016/j.neuron.2011.02.006
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Cortical pyramidal neurons receive thousands of synaptic inputs arriving at different dendritic locations with varying degrees of temporal synchrony. It is not known if different locations along single cortical dendrites integrate excitatory inputs in different ways. Here we have used two-photon glutamate uncaging and compartmental modeling to reveal a gradient of nonlinear synaptic integration in basal and apical oblique dendrites of cortical pyramidal neurons. Excitatory inputs to the proximal dendrite sum linearly and require precise temporal coincidence for effective summation, whereas distal inputs are amplified with high gain and integrated over broader time windows. This allows distal inputs to overcome their electrotonic disadvantage, and become surprisingly more effective than proximal inputs at influencing action potential output. Thus, single dendritic branches can already exhibit non-uniform synaptic integration, with the computational strategy shifting from temporal coding to rate coding along the dendrite.
引用
收藏
页码:885 / 892
页数:8
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