Multifunctional deadenylase complexes diversify mRNA control

被引：314

作者：

Goldstrohm, Aaron C. ^{[1
]}

Wickens, Marvin ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 04期

关键词：

D O I：

10.1038/nrm2370

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dynamic changes of the lengths of mRNA poly(A) tails are catalysed by diverse deadenylase enzymes. Modulating the length of the poly(A) tail of an mRNA is a widespread means of controlling protein production and mRNA stability. Recent insights illuminate the specialized activities, biological functions and regulation of deadenylases. We propose that the recruitment of multifunctional deadenylase complexes provides unique opportunities to control mRNAs and that the heterogeneity of the deadenylase complexes is exploited to control translation and mRNA stability.

引用

页码：337 / 344

页数：8

共 76 条

[11] Computational modeling of eukaryotic mRNA turnover [J].

Cao, D ;

Parker, R .

RNA, 2001, 7 (09) :1192-1212

[12] UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by thr c-fos major coding-region determinant [J].

Chang, TC ;

Yamashita, A ;

Chen, CYA ;

Yamashita, Y ;

Zhu, WM ;

Durdan, S ;

Kahvejian, A ;

Sonenberg, N ;

Shyu, AB .

GENES & DEVELOPMENT, 2004, 18 (16) :2010-2023

[13] Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway [J].

Chen, CYA ;

Shyu, AB .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (14) :4805-4813

[14] AtPARN is an essential poly(A) ribonuclease in Arabidopsis [J].

Chiba, Y ;

Johnson, MA ;

Lidder, P ;

Vogel, JT ;

van Erp, H ;

Green, PJ .

GENE, 2004, 328 :95-102

[15] Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay [J].

Chou, Chu-Fang ;

Mulky, Alok ;

Maitra, Sushmit ;

Lin, Wei-Jye ;

Gherzi, Roberto ;

Kappes, John ;

Chen, Ching-Yi .

MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (10) :3695-3706

[16] Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54 [J].

Chu, Chia-ying ;

Rana, Tariq M. .

PLOS BIOLOGY, 2006, 4 (07) :1122-1136

[17] RNA-binding proteins in early development [J].

Colegrove-Otero, LJ ;

Minshall, N ;

Standart, N .

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2005, 40 (01) :21-73

[18] Mutational analysis of a viral RNA element that counteracts rapid RNA decay by interaction with the polyadenylate tail [J].

Conrad, Nicholas K. ;

Shu, Mei-Di ;

Uyhazi, Katherine E. ;

Steitz, Joan A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (25) :10412-10417

[19] The CCR4-NOT complex plays diverse roles in mRNA metabolism [J].

Denis, CL ;

Chen, JJ .

PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, VOL 73, 2003, 73 :221-250

[20] Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases [J].

Dlakic, M .

TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (06) :272-273

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