No association between serotonin 2A receptor gene variants and personality traits

被引：22

作者：

Jönsson, EG

Nöthen, MM

Gustavsson, JP

Berggård, C

Bunzel, R

Forslund, K

Rylander, G

Mattila-Evenden, M

Propping, P

Åsberg, M

Sedvall, G

机构：

[1] Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, SE-17176 Stockholm, Sweden

[2] Univ Bonn, Inst Human Genet, D-5300 Bonn, Germany

[3] Univ Antwerp, Dept Med Genet, Antwerp, Belgium

[4] Karolinska Inst, Dept Nursing, Stockholm, Sweden

[5] Uppsala Univ, Dept Neurosci, Pharmacol Sect, Uppsala, Sweden

来源：

PSYCHIATRIC GENETICS | 2001年 / 11卷 / 01期

关键词：

serotonin; 5-HT2A; genetics; association study; Karolinska Scales of Personality;

D O I：

10.1097/00041444-200103000-00003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Among theories of biological underpinnings to personality traits, different mechanisms of the serotonergic system are perhaps the most common factors suggested to influence individual differences in personality traits. We have investigated two frequent variants in the serotonin 2A receptor gene (5-HT2A) and personality traits. Healthy Swedish subjects (n = 304) were assessed with the Karolinska Scales of Personality (KSP) inventory. After correction for multiple testing, no significant differences were found. We conclude that the investigated 5-HT2A gene variants do not significantly influence personality as assessed by the KSP in the present population. Psychiatr Genet 11:11-17 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：11 / 17

页数：7

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