Total Syntheses of Angelicoin A, Hericenone J, and Hericenol A via Migratory Prenyl- and Geranylation-Aromatization Sequences

被引：32

作者：

Cordes, Jens ^{[1
]}

Calo, Frederick ^{[1
]}

Anderson, Katie ^{[1
]}

Pfaffeneder, Toni ^{[1
]}

Laclef, Sylvain ^{[1
]}

White, Andrew J. P. ^{[1
]}

Barrett, Anthony G. M. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AZ, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 01期

基金：

英国工程与自然科学研究理事会; 欧洲研究理事会;

关键词：

GAMMA-UNSATURATED ALCOHOLS; NATURAL-PRODUCTS; MACARANGA-SCHWEINFURTHII; ETHYL ACETOACETATE; BROWN ALGA; ANTIFUNGAL; FLAVONOIDS; CHALCONES; ACID; REARRANGEMENT;

D O I：

10.1021/jo202354j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A five-step synthesis of the natural product angelicoin A using a late stage highly regioselective palladium(0)-catalyzed decarboxylative prenyl migration and aromatization sequence as the key step is reported. The method was extended with geranyl migration in eight-step total syntheses of hericenone J and hericenol A from geraniol.

引用

页码：652 / 657

页数：6

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